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Mechanism of Action Comparison Retatrutide: Triple Agonist Mechanism Retatrutide activates three distinct receptor systems: GLP-1 receptor : Enhances glucose-dependent insulin secretion, suppresses glucagon, delays gastric emptying, activates satiety circuits GIP receptor : Amplifies insulin secretion, promotes adipose lipid storage, supports bone formation Glucagon receptor : Increases hepatic glucose output, stimulates lipolysis, raises energy expenditure The triple agonism creates a balanced metabolic profile where the glucagon component counteracts the insulinotropic effects of GLP-1 and GIP, producing unique research questions about metabolic signal integration
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